Washington, D.C. 20549
Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): February 28, 2024
(Exact name of registrant as specified in its charter)
(State or other jurisdiction
of incorporation)
(Commission File Number)
(I.R.S. Employer
Identification No.)
2701 Eastlake Avenue East
Seattle, Washington
(Address of principal executive offices)
(Zip code)
(206) 333-2001
(Registrant’s telephone number, including area code)

(Former name or former address, if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
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Securities registered pursuant to Section 12(b) of the Act:
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Common Stock, par value $0.0001 per share
The Nasdaq Stock Market LLC
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company  x
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Item 2.02.    Results of Operations and Financial Condition.
On February 28, 2024, Nautilus Biotechnology, Inc. issued a press release reporting its financial results for the quarter and fiscal year ended December 31, 2023. A copy of the press release is furnished herewith as Exhibit 99.1 to this Current Report on Form 8-K.
The information furnished in this Current Report under Item 2.02 and the exhibit attached hereto shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing.
Item 9.01.    Financial Statements and Exhibits.
(d)    Exhibits
104Cover page Interactive Data File (embedded with the Inline XBRL document)

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Dated: February 28, 2024
By:/s/ Sujal Patel
Name:Sujal Patel
Title:Chief Executive Officer

Exhibit 99.1
Nautilus Biotechnology Reports Fourth Quarter and Fiscal Year 2023 Financial Results
SEATTLE, WA, February 28, 2024 – Nautilus Biotechnology, Inc. (NASDAQ: NAUT; or “Nautilus”), a company pioneering a single molecule proteome analysis platform, today reported financial results for the fourth quarter and fiscal year ended December 31, 2023.

“2023 was a year of significant accomplishment and foundational progress for Nautilus; progress that will continue to build our momentum as we move through 2024 and into the planned launch of our proteome analysis platform”, said Sujal Patel, CEO of Nautilus. “We are building a groundbreaking, ‘first-in-the-world’ platform designed to unlock significant breakthroughs in biological research. Doing so requires that a number of meaningful innovations across each element of our platform - consumables, instrument, and software - weave together seamlessly. We continue to refine each of these platform elements and look forward to getting the collective work of our team into the hands of researchers where it can do so much good. I’m particularly pleased that we’ve been able to drive such meaningful scientific progress while maintaining exceptional fiscal discipline and preserving our balance sheet.”
Fiscal Year 2023 Financial Results
Operating expenses were $76.2 million for the year ended December 31, 2023, a $12.5 million or 20% increase from $63.6 million for the year ended December 31, 2022. The increase in operating expenses was driven primarily by an increase in headcount to support ongoing development of our products.
Net loss was $63.7 million for the year ended December 31, 2023, as compared to a net loss of $57.9 million for the corresponding prior year period.
Cash, cash equivalents, and investments were $264.1 million as of December 31, 2023.

Fiscal Year 2024 Outlook
We expect full year operating expense to grow by approximately 25% relative to 2023
We expect that cash and cash equivalents and investments of $264.1 million as of December 31, 2023 to provide a runway into the second half of 2026
We expect to launch our platform, instruments, consumables, and software in 2025.
Webcast and Conference Call Information
Nautilus will host a conference call to discuss the fourth quarter and fiscal year 2023 financial results, business developments and outlook before market open on Wednesday, February 28, 2024 at 5:30 AM Pacific Time / 8:30 AM Eastern Time. Live audio of the webcast will be available on the “Investors” section of the company website at:
About Nautilus Biotechnology, Inc.
With its corporate headquarters in Seattle, Washington and its research and development headquarters in San Carlos, California, Nautilus is a development stage life sciences company working to create a platform technology for quantifying and unlocking the complexity of the proteome. Nautilus’ mission is to transform the field of proteomics by democratizing access to the proteome and enabling fundamental advancements across human health and medicine. To learn more about Nautilus, visit
Special Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of federal securities laws. Forward-looking statements in this press release include, but are not limited to, statements regarding Nautilus’ expectations regarding the company’s business operations, financial performance and results of operations; expectations with respect to any revenue timing or projections, expectations with respect to the timing of the launch of Nautilus’ product platform and full commercial availability, the functionality and performance of Nautilus’ product platform, its potential impact on providing proteome access, pharmaceutical development and drug discovery, expanding research horizons, and enabling scientific explorations and discovery, and the present and future capabilities and limitations of emerging proteomics technologies. These statements are based on numerous assumptions concerning the development of Nautilus’ products, target markets, and other current and emerging proteomics technologies, and involve substantial risks, uncertainties and other factors that may cause actual results to be materially different from the information expressed or implied by these forward-looking statements. Risks and uncertainties

that could materially affect the accuracy of Nautilus’ assumptions and its ability to achieve the forward-looking statements set forth in this press release include (without limitation) the following: Nautilus’ product platform is not yet commercially available and remains subject to significant scientific and technical development, which is inherently challenging and difficult to predict, particularly with respect to highly novel and complex products such as those being developed by Nautilus. Even if our development efforts are successful, our product platform will require substantial validation of its functionality and utility in life science research. In the course of Nautilus’ scientific and technical development and associated product validation and commercialization, we may experience material delays as a result of unanticipated events. We cannot provide any guarantee or assurance with respect to the outcome of our development, collaboration, and commercialization initiatives or with respect to their associated timelines. For a more detailed description of additional risks and uncertainties facing Nautilus and its development efforts, investors should refer to the information under the caption “Risk Factors” in our Annual Report on Form 10-K to be filed for the year ended December 31, 2023 and our other filings with the SEC. The forward-looking statements in this press release are as of the date of this press release. Except as otherwise required by applicable law, Nautilus disclaims any duty to update any forward-looking statements. You should, therefore, not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release.

Disclosure Information

Nautilus uses filings with the Securities and Exchange Commission, its website (, press releases, public conference calls, public webcasts, and its social media accounts as means of disclosing material non-public information and for complying with Regulation FD. Therefore, Nautilus encourages investors, the media, and others interested in Nautilus to review the information it makes public in these locations, as such information could be deemed to be material information.
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Nautilus Biotechnology, Inc.
Consolidated Balance Sheets
As of December 31, 2023 and 2022 (Unaudited)
(in thousands, except share and per share amounts)December 31, 2023December 31, 2022
Current assets:
Cash and cash equivalents$19,397 $114,523 
Short-term investments154,021 69,948 
Prepaid expenses and other current assets3,419 2,738 
Total current assets176,837 187,209 
Property and equipment, net4,267 3,700 
Operating lease right-of-use assets32,634 28,866 
Long-term investments90,647 129,169 
Other long-term assets1,180 1,108 
Total assets$305,565 $350,052 
Liabilities and Stockholders’ Equity
Current liabilities:
Accounts payable$1,639 $1,272 
Accrued expenses and other liabilities3,945 3,528 
Current portion of operating lease liability3,538 1,991 
Total current liabilities9,122 6,791 
Operating lease liability, net of current portion31,090 28,337 
Total liabilities40,212 35,128 
Stockholders’ equity:
Preferred stock— — 
Common stock13 12 
Additional paid-in capital467,834 455,330 
Accumulated other comprehensive loss(255)(1,854)
Accumulated deficit(202,239)(138,564)
Total stockholders’ equity265,353 314,924 
Total liabilities and stockholders’ equity$305,565 $350,052 


Nautilus Biotechnology, Inc.
Consolidated Statements of Operations
Three Months and Year Ended December 31, 2023 and 2022 (Unaudited)
Three Months Ended December 31,Year Ended December 31,
(in thousands, except share and per share amounts)2023202220232022
Operating expenses:
Research and development$12,466 $9,587 $47,251 $37,672 
General and administrative7,535 6,717 28,901 25,946 
Total operating expenses20,001 16,304 76,152 63,618 
Other income (expense):
Interest income3,033 2,887 12,550 5,816 
Other expense(56)(73)(122)
Total other income$2,977 $2,895 $12,477 $5,694 
Net loss$(17,024)$(13,409)$(63,675)$(57,924)
Net loss per share attributable to common stockholders, basic and diluted$(0.14)$(0.11)$(0.51)$(0.46)
Weighted-average shares used in computing net loss per share attributable to common stockholders, basic and diluted124,984,918 124,789,542 124,919,144 124,589,555 


Nautilus Biotechnology, Inc.
Consolidated Statements of Cash Flows
Year Ended December 31, 2023 and 2022 (Unaudited)

Year Ended December 31,
(in thousands)20232022
Cash flows from operating activities
Net loss$(63,675)$(57,924)
Adjustments to reconcile net loss to net cash used in operating activities
Stock-based compensation12,137 10,380 
Amortization of operating lease right-of-use assets3,856 2,199 
Depreciation1,849 1,217 
Amortization (accretion) of premiums (discount) on securities, net(2,659)(890)
Changes in operating assets and liabilities:
Prepaid expenses and other assets(821)756 
Accounts payable393 (561)
Accrued expenses and other liabilities417 409 
Operating lease liabilities(3,208)(1,392)
Net cash used in operating activities(51,711)(45,806)
Cash flows from investing activities
Purchases of securities (112,892)(186,591)
Purchases of property and equipment(2,442)(2,324)
Proceeds from maturities of securities 71,599 163,175 
Net cash used in investing activities(43,735)(25,740)
Cash flows from financing activities
Proceeds from exercise of stock options104 330 
Proceeds from issuance of common stock under employee stock purchase plan264 232 
Net cash provided by financing activities368 562 
Net decrease in cash, cash equivalents and restricted cash
Cash, cash equivalents and restricted cash at beginning of period115,477 186,461 
Cash, cash equivalents and restricted cash at end of period$20,399 $115,477