Document
As filed with the Securities and Exchange Commission on April 7, 2021
No. 333-254796
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Amendment No. 1
to
FORM S-4
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
ARYA SCIENCES ACQUISITION CORP III*
(Exact name of registrant as specified in its charter)
Cayman Islands*677098-1541723
(State or other jurisdiction of incorporation
or organization)
(Primary Standard Industrial
Classification Code Number)
(I.R.S. Employer Identification No.)
51 Astor Place, 10th Floor
New York, NY 10003
Tel.: (212) 284-2300
(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)
Adam Stone
51 Astor Place, 10th Floor
New York, New York 10003
Tel.: (212) 284-2300
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies of all communications, including communications sent to agent for service, should be sent to:
Christian O. Nagler, Esq.
Peter Seligson, Esq.
Kirkland & Ellis LLP
601 Lexington Avenue
New York, New York 10022
Tel: (212) 446-4800
Fax: (212) 446-4900
Robert F. Kornegay
Michael Nordtvedt
Brian Keyes
Zachary B. Myers
Wilson Sonsini Goodrich & Rosati, P.C.
650 Page Mill Road
Palo Alto, California 94304
Tel: (650) 493-9300
Fax: (650) 493-6811
Approximate date of commencement of proposed sale of the securities to the public: As soon as practicable after this Registration Statement becomes effective.
If the securities being registered on this Form are being offered in connection with the formation of a holding company and there is compliance with General Instruction G, check the following box.  ☐
If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.  ☐
If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.  ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large accelerated filerAccelerated filer
Non-accelerated filerSmaller reporting company
Emerging growth company
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.  ☐
If applicable, place an X in the box to designate the appropriate rule provision relied upon in conducting this transaction:
Exchange Act Rule 13e-4(i) (Cross-Border Issuer Tender Offer)  ☐
Exchange Act Rule 14d-l(d) (Cross-Border Third-Party Tender Offer)  ☐



CALCULATION OF REGISTRATION FEE
Title of Each Class of Securities
to be Registered
Amount
to be
Registered(2)
Proposed
Maximum
Offering Price
Per Share
Proposed Maximum Aggregate
Offering Price(1)
Amount of Registration Fee
New Nautilus Common Stock(1)
111,674,810 
$12.02 (3)
$1,342,331,216 
$146,449 (4)
Total111,674,810 
$146,449 (4)(5)
(1)The number of shares of common stock of New Nautilus (as defined below) being registered represents (i) 14,950,000 Class A ordinary shares issued in ARYA’s initial public offering, which will be converted by operation of law into shares of common stock of New Nautilus (the “New Nautilus Common Stock”) in the Domestication (each as defined below) (ii) 499,000 Class A ordinary shares issued in a private placement simultaneously with the closing of ARYA’s initial public offering which will be converted by operation of law into shares of New Nautilus Common Stock in the Domestication, (iii) 3,737,500 Class B ordinary shares held by ARYA’s initial shareholders which will be converted by operation of law into shares of New Nautilus Common Stock in the Domestication, (iv) up to 85,295,562  shares of New Nautilus Common Stock that will be issued to the equity holders of Nautilus Biotechnology, Inc. in connection with the Business Combination described in the proxy statement/prospectus forming part of this registration statement (the “proxy statement/prospectus”), assuming an exchange ratio of 3.6275, and (v) up to 7,192,748 shares of New Nautilus Common Stock that may be issued upon the exercise of outstanding options to purchase shares of Nautilus Biotechnology, Inc. common stock being assumed in connection with the Business Combination, assuming an exchange ratio of 3.6275.
(2)Pursuant to Rule 416(a) of Securities Act of 1933, as amended (the “Securities Act”), there are also being registered an indeterminable number of additional securities as may be issued to prevent dilution resulting from stock splits, stock dividends or similar transactions.
(3)Estimated solely for the purpose of calculating the registration fee, based on the average of the high and low prices of the Class A ordinary shares of ARYA on the Nasdaq Capital Market on  March 25 , 2021 ($12.02  per Class A ordinary share). This calculation is in accordance with Rule 457(f)(1) of the Securities Act.
(4)Calculated by multiplying the proposed maximum aggregate offering price of securities to be registered by 0.0001091.
(5)Previously paid.
*Immediately prior to the consummation of the Business Combination, ARYA Sciences Acquisition Corp III, a Cayman Islands exempted company (“ARYA”), intends to effect a deregistration under the Cayman Islands Companies Act (2021 Revision) and a domestication under Section 388 of the Delaware General Corporation Law, pursuant to which ARYA’s jurisdiction of incorporation will be changed from the Cayman Islands to the State of Delaware (the “Domestication”). All securities being registered will be issued by the continuing entity following the Domestication, which will be renamed “Nautilus Biotechnology, Inc.” upon the consummation of the Domestication. As used herein, “New Nautilus” refers to ARYA after giving effect to the Domestication.
The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act or until the registration statement shall become effective on such date as the SEC, acting pursuant to Section 8(a), may determine.



EXPLANATORY NOTE
ARYA Sciences Acquisition Corp III is filing this Amendment No. 1 (the “Amendment”) to its registration statement on Form S-4 (File No. 333-254796) (the “Registration Statement”) as an exhibits-only filing. Accordingly, this Amendment consists only of the facing page, this explanatory note, Item 21(a) of Part II of the Registration Statement, the signature page to the Registration Statement and the filed exhibits. The remainder of the Registration Statement is unchanged and has therefore been omitted.



PART II
INFORMATION NOT REQUIRED IN PROSPECTUS
Item 21. Exhibits and Financial Statements Schedules
(a) Exhibits.
Exhibit
Number
Description
2.1*†
3.1*
3.2*
3.3*
4.1*
4.2**Form of Certificate of Corporate Domestication of ARYA, to be filed with the Secretary of the State of Delaware.
5.1*
8.1
10.1*
10.2*
10.3*
10.4*
10.5*+
10.6*+
10.7*+
10.8*+
10.9*+
10.10*
10.11*+
10.12**+Confirmatory Employment Letter between Nautilus Biotechnology, Inc. and Sujal Patel.
10.13**+Confirmatory Employment Letter between Nautilus Biotechnology, Inc. and Anna Mowry.
10.14**+Confirmatory Employment Letter between Nautilus Biotechnology, Inc. and Nick Nelson.
10.15**+Confirmatory Employment Letter between Nautilus Biotechnology, Inc. and Subra Sankar.
10.16**+Confirmatory Employment Letter between Nautilus Biotechnology, Inc. and Parag Mallick.
10.17**+Change in Control and Severance Agreement between Nautilus Biotechnology, Inc. and Sujal Patel
10.18**+Change in Control and Severance Agreement between Nautilus Biotechnology, Inc. and Anna Mowry
10.19**+Change in Control and Severance Agreement between Nautilus Biotechnology, Inc. and Nick Nelson
II-1


Exhibit
Number
Description
10.20**+Change in Control and Severance Agreement between Nautilus Biotechnology, Inc. and Subra Sankar
10.21**+Change in Control and Severance Agreement between Nautilus Biotechnology, Inc. and Parag Mallick
10.22**Form of New Nautilus Indemnification Agreement.
21.1*
23.1*
23.2*
23.3*
23.4
24.1*
99.1*
99.2*
99.3*
99.4*
99.5*
99.6*
99.7*
99.8*
__________________
*    Previously filed.
**    To be filed by amendment.
+    Indicates management contract or compensatory plan.
†    Certain confidential portions (indicated by brackets and asterisks) have been omitted from this exhibit.
††    Schedules and exhibits to this Exhibit omitted pursuant to Regulation S-K Item 601(b)(2). The Registrant agrees to furnish supplementally a copy of any omitted schedule of exhibit to the SEC upon request.
II-2


SIGNATURES
Pursuant to the requirements of the Securities Act, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New York, State of New York on the 7th of April, 2021.
ARYA SCIENCES ACQUISITION CORP III
By:/s/ Adam Stone
Name: Adam Stone
Title: Chief Executive Officer
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed below by the following persons in the capacities and on the dates indicated.
NAMEPOSITIONDATE
*Chairman of the Board of DirectorsApril 7, 2021
Joseph Edelman
/s/ Adam StoneChief Executive Officer and Director
(Principal Executive Officer)
April 7, 2021
Adam Stone
*Chief Financial Officer and Director
(Principal Financial and Accounting Officer)
April 7, 2021
Michael Altman
*DirectorApril 7, 2021
Todd Wider
*DirectorApril 7, 2021
Bradley L. Campbell
*DirectorApril 7, 2021
Saqib Islam
*By: /s/ Adam Stone
Adam Stone
Attorney-in-Fact
II-3
Document
Exhibit 8.1
https://cdn.kscope.io/ebe83203e9943b7cda76e58040474441-image_11.jpg
601 Lexington Avenue
New York, NY 10022
United States
+1 212 446 4800
www.kirkland.com
Facsimile:
+1 212 446 4900



April 7, 2021

ARYA Sciences Acquisition Corp III
51 Astor Place, 10th Floor
New York, New York 10003

Ladies and Gentlemen:
We are United States tax counsel to ARYA Sciences Acquisition Corp III, a Cayman Islands exempted company (“ARYA”), in connection with the preparation of the registration statement on Form S-4 (as amended, and together with the Proxy Statement/Prospectus filed therewith, the “Registration Statement”) (Registration No. 333-254796) originally filed with the Securities and Exchange Commission (the “Commission”) on March 26, 2021, under the Securities Act of 1933, as amended (the “Securities Act”), by ARYA. The Registration Statement relates to the registration of 111,674,810 shares of common stock of Nautilus Biotechnology, Inc., a Delaware corporation (“New Nautilus”).
The Registration Statement is being filed in connection with the transactions contemplated by the Business Combination Agreement, dated as of February 7, 2021 (the “Business Combination Agreement”), by and among ARYA, Mako Merger Sub, Inc., a Delaware corporation and Nautilus Biotechnology, Inc., a Delaware corporation (“Nautilus”) (such transactions, including the Domestication, the “Business Combination”).
Capitalized terms not otherwise defined herein shall have the same meanings attributed to such terms in the Registration Statement.
You have requested our opinion concerning the discussion of the Domestication set forth in the section entitled “Material U.S. Federal Income Tax Consequences—U.S. Holders—Effect of the Domestication on U.S. Holders” in the Registration Statement (the “Tax Disclosure”). In providing this opinion, we have assumed (without any independent investigation or review thereof) that:
a.All original documents submitted to us (including signatures thereto) are authentic, all documents submitted to us as copies conform to the original documents, all such documents have been duly and validly executed and delivered where due execution and delivery are a prerequisite to the effectiveness thereof, and all parties to such documents had or will have, as applicable, the requisite corporate powers and authority to enter into such documents and to undertake and consummate the Business Combination;
Beijing   Boston   Chicago   Dallas   Hong Kong   Houston   London   Los Angeles   Munich   Palo Alto   Paris   San Francisco   Shanghai   Washington, D.C.


https://cdn.kscope.io/ebe83203e9943b7cda76e58040474441-image_01.jpg
ARYA Sciences Acquisition Corp III
April 7, 2021
Page 2

b.All factual representations, warranties and statements made or agreed to by the parties to the Business Combination Agreement, the Sponsor Letter Agreement, and the other agreements referred to in each of the foregoing (collectively, the “Agreements” and, together with the Registration Statement, the “Documents”), and in the representation letter provided to us by ARYA, are true, correct and complete as of the date hereof and will remain true, correct and complete through the consummation of Transactions (as defined below), in each case without regard to any qualification as to knowledge, belief, materiality, or otherwise;
c.The descriptions of ARYA in the Registration Statement, the registration statement filed in connection with ARYA’s initial public offering, and ARYA’s other public filings are true, accurate and complete;
d.The description of the Business Combination and other transactions related to the Business Combination (together, the “Transactions”) in the Registration Statement is and will remain true, accurate and complete, the Business Combination will be consummated in accordance with such description and with the Business Combination Agreement and the other Agreements, without any waiver or breach of any material provision thereof, and the Business Combination will be effective under applicable corporate law as described in the Business Combination Agreement and the other Agreements; and
e.The Documents represent the entire understanding of the parties with respect to the Business Combination and other Transactions, there are no other written or oral agreements regarding the Transactions other than the Agreements, and none of the material terms and conditions thereof have been or will be waived or modified.
This opinion is based on current provisions of the U.S. Internal Revenue Code of 1986, as amended (the “Code”), the U.S. Treasury Regulations promulgated thereunder, and the interpretation of the Code and such regulations by the courts and the U.S. Internal Revenue Service, in each case, as they are in effect and exist at the date of this opinion. It should be noted that statutes, regulations, judicial decisions and administrative interpretations are subject to change at any time and, in some circumstances, with retroactive effect. Any change that is made after the date hereof in any of the foregoing bases for our opinion, or any inaccuracy in the facts or assumptions on which we have relied in issuing our opinion, could adversely affect our conclusion. We assume no responsibility to inform you of any such change or inaccuracy that may occur or come to our attention or to supplement or revise our opinion to reflect any legal developments or factual matters arising subsequent to the date hereof. No opinion is expressed as to any transactions other than the Domestication in connection with the Business Combination, or any matter other than those specifically covered by this opinion. In particular, this opinion is limited to the matters discussed in the Tax Disclosure, and does not address (i) the U.S. federal income tax treatment of any shareholder subject to special rules under the Code or the Treasury Regulations, as further described in the Tax Disclosure, (ii) any matter arising in connection with


https://cdn.kscope.io/ebe83203e9943b7cda76e58040474441-image_01.jpg
ARYA Sciences Acquisition Corp III
April 7, 2021
Page 3

Section 367 of the Code, or (iii) any matter arising in connection with the “passive foreign investment company” rules of Sections 1291-1297 of the Code.
The U.S. federal income tax consequences of the transactions described in the Registration Statement are complex and are subject to varying interpretations. Our opinion is not binding on the U.S. Internal Revenue Service or any court, and there can be no assurance or guarantee that either will agree with our conclusions. Indeed, the U.S. Internal Revenue Service may challenge one or more of the conclusions contained herein and the U.S. Internal Revenue Service may take a position that is inconsistent with the views expressed herein. There can be no assurance or guarantee that a court would, if presented with the issues addressed herein, reach the same or similar conclusions as we have reached.
Based upon and subject to the foregoing, we confirm that the statements set forth in the Registration Statement under the heading “Material U.S. Federal Income Tax Consequences—U.S. Holders—Effect of the Domestication on U.S. Holders,” insofar as they address the material U.S. federal income tax considerations for beneficial owners of ARYA Class A Shares of the Domestication, and discuss matters of U.S. federal income tax law and regulations or legal conclusions with respect thereto, and except to the extent stated otherwise therein, are our opinion, subject to the assumptions, qualifications and limitations stated herein and therein.

This opinion is furnished to you solely for use in connection with the Registration Statement. This opinion is based on facts and circumstances existing on the date hereof. We hereby consent to the filing of this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby concede that we are within the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission thereunder.
Very truly yours,
/s/ Kirkland & Ellis LLP
Kirkland & Ellis LLP