<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:a9f6a10c-e70d-4b58-9e50-1514a7d91870,g:c6916c76-49f1-44ea-b901-701b43f978e5-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="arya-20210424.xsd#DocumentandEntityInformation"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/DocumentandEntityInformation" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/UNAUDITEDCONDENSEDBALANCESHEET" xlink:type="simple" xlink:href="arya-20210424.xsd#UNAUDITEDCONDENSEDBALANCESHEET"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/UNAUDITEDCONDENSEDBALANCESHEET" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_06fe7b61-ef85-40a5-a14d-916fd13ebfa5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_656092ce-67a6-43ef-ad4f-12837309f222" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_06fe7b61-ef85-40a5-a14d-916fd13ebfa5" xlink:to="loc_us-gaap_Liabilities_656092ce-67a6-43ef-ad4f-12837309f222" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_27c331b9-f089-423b-ac48-8f9a150d25e9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TemporaryEquityCarryingAmountAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_06fe7b61-ef85-40a5-a14d-916fd13ebfa5" xlink:to="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_27c331b9-f089-423b-ac48-8f9a150d25e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_4cb9ecfc-79be-4082-b10f-26af8dd86cfa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_06fe7b61-ef85-40a5-a14d-916fd13ebfa5" xlink:to="loc_us-gaap_StockholdersEquity_4cb9ecfc-79be-4082-b10f-26af8dd86cfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_3114b3fc-2c47-4806-a3ad-04d7185dba77" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_b5b0fc57-8c39-4315-b0ba-32a48424592b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3114b3fc-2c47-4806-a3ad-04d7185dba77" xlink:to="loc_us-gaap_LiabilitiesCurrent_b5b0fc57-8c39-4315-b0ba-32a48424592b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_arya_DeferredUnderwritingFeePayableNonCurrent_b85c51b5-f084-4204-b7de-195397894876" xlink:href="arya-20210424.xsd#arya_DeferredUnderwritingFeePayableNonCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3114b3fc-2c47-4806-a3ad-04d7185dba77" xlink:to="loc_arya_DeferredUnderwritingFeePayableNonCurrent_b85c51b5-f084-4204-b7de-195397894876" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_d8cba764-95d6-4d8c-b2cb-59b5e84ed0b1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_f9045e57-11c5-4834-a87f-379589129eee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_d8cba764-95d6-4d8c-b2cb-59b5e84ed0b1" xlink:to="loc_us-gaap_PreferredStockValue_f9045e57-11c5-4834-a87f-379589129eee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_e41bb371-26eb-4f01-8933-c28fa5a0ad63" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_d8cba764-95d6-4d8c-b2cb-59b5e84ed0b1" xlink:to="loc_us-gaap_CommonStockValue_e41bb371-26eb-4f01-8933-c28fa5a0ad63" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_21b5671f-e7d8-4332-a0df-8caa9425df89" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_d8cba764-95d6-4d8c-b2cb-59b5e84ed0b1" xlink:to="loc_us-gaap_AdditionalPaidInCapital_21b5671f-e7d8-4332-a0df-8caa9425df89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_a092053f-a21e-4fe8-81b4-17794e2ceec0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_d8cba764-95d6-4d8c-b2cb-59b5e84ed0b1" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_a092053f-a21e-4fe8-81b4-17794e2ceec0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_a57e06e6-f6f2-44bc-a1b6-0838cab676a8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_ef7fcbe1-f8cc-4004-bacb-f61a84f878b5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_a57e06e6-f6f2-44bc-a1b6-0838cab676a8" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_ef7fcbe1-f8cc-4004-bacb-f61a84f878b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_38df1b54-fb3f-4f68-9d21-1bb0a7a44d62" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Cash_b9890a01-eced-4b8d-8d25-b78fc58ad9d2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Cash"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_38df1b54-fb3f-4f68-9d21-1bb0a7a44d62" xlink:to="loc_us-gaap_Cash_b9890a01-eced-4b8d-8d25-b78fc58ad9d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_2d98f9b8-82e8-4d64-91f8-2fead9d55ae7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_38df1b54-fb3f-4f68-9d21-1bb0a7a44d62" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_2d98f9b8-82e8-4d64-91f8-2fead9d55ae7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_e5e3fefb-b621-4695-8e62-fd15299bc445" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_7bdcd424-9162-49d0-973a-a04354c1152e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e5e3fefb-b621-4695-8e62-fd15299bc445" xlink:to="loc_us-gaap_AssetsCurrent_7bdcd424-9162-49d0-973a-a04354c1152e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsHeldInTrustNoncurrent_45ab8980-11ef-4983-b1c3-f4bb5708b936" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsHeldInTrustNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e5e3fefb-b621-4695-8e62-fd15299bc445" xlink:to="loc_us-gaap_AssetsHeldInTrustNoncurrent_45ab8980-11ef-4983-b1c3-f4bb5708b936" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/UNAUDITEDCONDENSEDBALANCESHEETParenthetical" xlink:type="simple" xlink:href="arya-20210424.xsd#UNAUDITEDCONDENSEDBALANCESHEETParenthetical"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/UNAUDITEDCONDENSEDBALANCESHEETParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/UNAUDITEDCONDENSEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="arya-20210424.xsd#UNAUDITEDCONDENSEDSTATEMENTSOFOPERATIONS"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/UNAUDITEDCONDENSEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_04e4596b-d4ec-4f07-b18c-ad77eba2f3dd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_1633ee6b-daaa-45d5-a899-0d8bc0fee875" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_04e4596b-d4ec-4f07-b18c-ad77eba2f3dd" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_1633ee6b-daaa-45d5-a899-0d8bc0fee875" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_8df2aa80-b6f7-47a5-a68e-0bebcbceb318" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_b9cde219-c799-4359-aad2-c74ba823ae7b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_8df2aa80-b6f7-47a5-a68e-0bebcbceb318" xlink:to="loc_us-gaap_OperatingIncomeLoss_b9cde219-c799-4359-aad2-c74ba823ae7b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnInvestments_c73c39ca-20eb-440f-bb38-2c152d1f25ad" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_8df2aa80-b6f7-47a5-a68e-0bebcbceb318" xlink:to="loc_us-gaap_GainLossOnInvestments_c73c39ca-20eb-440f-bb38-2c152d1f25ad" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/UNAUDITEDCONDENSEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITY" xlink:type="simple" xlink:href="arya-20210424.xsd#UNAUDITEDCONDENSEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITY"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/UNAUDITEDCONDENSEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITY" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/UNAUDITEDCONDENSEDSTATEMENTOFCASHFLOWS" xlink:type="simple" xlink:href="arya-20210424.xsd#UNAUDITEDCONDENSEDSTATEMENTOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/UNAUDITEDCONDENSEDSTATEMENTOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_867ae790-03b5-4c76-a7be-19a9d84d534d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_arya_CashDepositedInTrustAccount_0c4f1779-1062-4b62-b449-a12a9413b75f" xlink:href="arya-20210424.xsd#arya_CashDepositedInTrustAccount"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_867ae790-03b5-4c76-a7be-19a9d84d534d" xlink:to="loc_arya_CashDepositedInTrustAccount_0c4f1779-1062-4b62-b449-a12a9413b75f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_39cb37ed-ea5c-4f15-b73f-f4f109df3204" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_996ab16a-89c5-48e8-ae54-6413bd55d89c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_39cb37ed-ea5c-4f15-b73f-f4f109df3204" xlink:to="loc_us-gaap_NetIncomeLoss_996ab16a-89c5-48e8-ae54-6413bd55d89c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnInvestments_c8479124-c9f2-4c0c-9417-c6cc92b596ad" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnInvestments"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_39cb37ed-ea5c-4f15-b73f-f4f109df3204" xlink:to="loc_us-gaap_GainLossOnInvestments_c8479124-c9f2-4c0c-9417-c6cc92b596ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionSellingGeneralAndAdministrativeExpensesFromTransactionsWithRelatedParty_19462fbc-6056-43be-80cc-21420da47131" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RelatedPartyTransactionSellingGeneralAndAdministrativeExpensesFromTransactionsWithRelatedParty"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_39cb37ed-ea5c-4f15-b73f-f4f109df3204" xlink:to="loc_us-gaap_RelatedPartyTransactionSellingGeneralAndAdministrativeExpensesFromTransactionsWithRelatedParty_19462fbc-6056-43be-80cc-21420da47131" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidExpensesOther_487f5a64-0957-4427-b45c-e6d49513e5e0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidExpensesOther"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_39cb37ed-ea5c-4f15-b73f-f4f109df3204" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidExpensesOther_487f5a64-0957-4427-b45c-e6d49513e5e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_4844c0a1-06c7-4ea4-be0d-5c99d5aa9f0e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_39cb37ed-ea5c-4f15-b73f-f4f109df3204" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_4844c0a1-06c7-4ea4-be0d-5c99d5aa9f0e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_6e4418e3-bc69-4951-97dc-a2693356dc2d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9769430f-c08c-4f89-8430-fc42178b81a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_6e4418e3-bc69-4951-97dc-a2693356dc2d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9769430f-c08c-4f89-8430-fc42178b81a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_91ccaed5-5731-4058-a6fa-8c12806b4ee6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_6e4418e3-bc69-4951-97dc-a2693356dc2d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_91ccaed5-5731-4058-a6fa-8c12806b4ee6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_c132b8f2-20b8-4097-9cc6-da8d1eb1fcb5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_6e4418e3-bc69-4951-97dc-a2693356dc2d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_c132b8f2-20b8-4097-9cc6-da8d1eb1fcb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_663f27a3-a9c4-45c9-b720-b3576d354159" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRelatedPartyDebt_d8308004-0dbf-4095-b539-629110ee60f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromRelatedPartyDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_663f27a3-a9c4-45c9-b720-b3576d354159" xlink:to="loc_us-gaap_ProceedsFromRelatedPartyDebt_d8308004-0dbf-4095-b539-629110ee60f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfRelatedPartyDebt_c14f5ff8-95ab-4171-85c4-984cbad104b6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfRelatedPartyDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_663f27a3-a9c4-45c9-b720-b3576d354159" xlink:to="loc_us-gaap_RepaymentsOfRelatedPartyDebt_c14f5ff8-95ab-4171-85c4-984cbad104b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_547b0a48-ffb9-409a-aae2-c4addfaacafd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceInitialPublicOffering"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_663f27a3-a9c4-45c9-b720-b3576d354159" xlink:to="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_547b0a48-ffb9-409a-aae2-c4addfaacafd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPrivatePlacement_5d0699c5-ddac-45ae-8c25-08f0457f8cf4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPrivatePlacement"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_663f27a3-a9c4-45c9-b720-b3576d354159" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPrivatePlacement_5d0699c5-ddac-45ae-8c25-08f0457f8cf4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_772b2904-ee43-4cb5-84e9-60fd51db380f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_663f27a3-a9c4-45c9-b720-b3576d354159" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_772b2904-ee43-4cb5-84e9-60fd51db380f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/DescriptionofOrganizationBusinessOperationsandBasisofPresentation" xlink:type="simple" xlink:href="arya-20210424.xsd#DescriptionofOrganizationBusinessOperationsandBasisofPresentation"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/DescriptionofOrganizationBusinessOperationsandBasisofPresentation" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/DescriptionofOrganizationBusinessOperationsandBasisofPresentationDetails" xlink:type="simple" xlink:href="arya-20210424.xsd#DescriptionofOrganizationBusinessOperationsandBasisofPresentationDetails"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/DescriptionofOrganizationBusinessOperationsandBasisofPresentationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="arya-20210424.xsd#SummaryofSignificantAccountingPolicies"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="arya-20210424.xsd#SummaryofSignificantAccountingPoliciesPolicies"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/SummaryofSignificantAccountingPoliciesDetails" xlink:type="simple" xlink:href="arya-20210424.xsd#SummaryofSignificantAccountingPoliciesDetails"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/SummaryofSignificantAccountingPoliciesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/InitialPublicOffering" xlink:type="simple" xlink:href="arya-20210424.xsd#InitialPublicOffering"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/InitialPublicOffering" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/InitialPublicOfferingDetails" xlink:type="simple" xlink:href="arya-20210424.xsd#InitialPublicOfferingDetails"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/InitialPublicOfferingDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/RelatedPartyTransactions" xlink:type="simple" xlink:href="arya-20210424.xsd#RelatedPartyTransactions"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/RelatedPartyTransactions" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/RelatedPartyTransactionsFounderSharesDetails" xlink:type="simple" xlink:href="arya-20210424.xsd#RelatedPartyTransactionsFounderSharesDetails"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/RelatedPartyTransactionsFounderSharesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/RelatedPartyTransactionsPromissoryNoteRelatedPartyLoansandAdministrativeSupportAgreementDetails" xlink:type="simple" xlink:href="arya-20210424.xsd#RelatedPartyTransactionsPromissoryNoteRelatedPartyLoansandAdministrativeSupportAgreementDetails"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/RelatedPartyTransactionsPromissoryNoteRelatedPartyLoansandAdministrativeSupportAgreementDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="arya-20210424.xsd#CommitmentsandContingencies"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/CommitmentsandContingencies" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/CommitmentsandContingenciesDetails" xlink:type="simple" xlink:href="arya-20210424.xsd#CommitmentsandContingenciesDetails"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/CommitmentsandContingenciesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/ShareholdersEquity" xlink:type="simple" xlink:href="arya-20210424.xsd#ShareholdersEquity"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/ShareholdersEquity" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/ShareholdersEquityDetails" xlink:type="simple" xlink:href="arya-20210424.xsd#ShareholdersEquityDetails"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/ShareholdersEquityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="arya-20210424.xsd#FairValueMeasurements"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/FairValueMeasurements" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="arya-20210424.xsd#FairValueMeasurementsTables"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/FairValueMeasurementsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="arya-20210424.xsd#FairValueMeasurementsDetails"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/FairValueMeasurementsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://perceptivelifearya3.com/role/SubsequentEvents" xlink:type="simple" xlink:href="arya-20210424.xsd#SubsequentEvents"/>
  <link:calculationLink xlink:role="http://perceptivelifearya3.com/role/SubsequentEvents" xlink:type="extended"/>
</link:linkbase>
